Cytokines Profile in Patients with Bacterial Sepsis and Septic Shock in Intensive Care Unit (ICU) of a Hospital in Colombia
Monica Chavez Vivas, Héctor Fabio Villamarín-Guerrero, Antonio J. Tascon

Introduction: The management of patients with sepsis in Intensive care unit (ICU) is a difficult task that may benefit from the use of non-invasive assessment by biomarkers. This study was conducted to evaluate early cytokine profile plasma (IL-1β, IL-6, IL-10 and TNF-α) in patients with sepsis and septic shock. Methods: A total of 62 patients with a recent diagnosis of sepsis and septic shock severe were included. Plasma samples were collected for measurement of cytokine concentrations. Plasma levels of cytokines were determined with enzyme-linked immunosorbent assays. Mann–Whitney U-test for the comparison of quantitative variables, χ2 test for qualitative variables. ROC curves of the variables were found to be significant in the multivariate analysis. Results: Patients who presented high levels of IL-1β (63%) and TNF-α (66.7%) during the first 48 hours, were more likely to develop septic shock (RR: 11,019, CI 2.782-43.643; RR: 8.444, CI 2.749-25.939, respectively).IL-1β and TNF-α plasma levels fairly a good predictor of septic shock during the first 48 hours of admission presented area under the curve0.916 and 0.890 (p< 0.001), respectively Conclusion: The results of this study suggest that IL-1βand TNF-α, are better in predicting to develop septic shock in the first 48 hours.

Full Text: PDF     DOI: 10.15640/ijhs.v8n2a2