The Immunohistochemical Examination of Changes that Take Place in PTEN Expression in Endometrioid Adenocarcinomas
Mesut Can, Nazlı Karagöz Can, Yusuf Kurtulmuş

Objective: Endometrial carcinomas are the most commonly seen malignant tumors of woman reproductive system and while they are estrogen-dependent in 80-85% of the cases, they are estrogen-independent in 10-15 % of the cases. Endometrioid adenocarcinomas are aggressive tumors which are estrogen-independent. PTEN (phosphatase and tensin homolog) is a tumor suppressor gene which frequently mutates in endometrial carcinomas. It is known that PTEN plays a suppressor role in the growth of the tumor and an inhibitor role in the development and metastasis. Material-Methods: In the study, it was aimed to immunohisto chemically examine the changes of PTEN expression in young patients who were diagnosed with endometrioid adenocarcinoma. 2 groups were created in the study. 1st Group; Control group: The group consisting of young people who were not diagnosed with endometrioid adenocarcinoma. 2nd Group; Patient Group: The group consisting of young people who were diagnosed with endometrioid adenocarcinoma. Result: Patient age which is included in the hospital archive, CEA, p53, myometrial invasion, lymphovascular invasion, and cervical invasion values were statistically evaluated between the control group and patient group and within the patient group. As a result of the evaluation conducted with the immunohistochemical method, it was observed that PTEN expression statistically decreased in the patient group and furthermore, when the patient group is evaluated within itself, it was determined that H-score values of Grade 3 patient group were statistically and significantly lower than the Grade1 patient group. Conclusion: It was observed that there was a decrease in the PTEN expression in endometrioid adenocarcinomas and this decrease is in correlation with the grade.

Full Text: PDF     DOI: 10.15640/ijhs.v7n3a7