Evaluation of Methionine and Related Metabolites in Hyperhomocysteinemia
Nurcan Kilic Baygutalp, Ebubekir Bakan, Hamit Hakan Alp, Nurinnisa Ozturk

Aim: This study was conducted to identify plasma methionine, S-adenosyl methionine (SAM), S-adenosyl homocysteine (SAH), folate, vitamin B12, cysteine levels on people whose diets were standardized and divided into 3 groups (low, middle and high) in terms of homocysteine level and aimed to comment on the fact that methionine was essential. Methods: Participitants were divided into three groups in terms of the homocsyteine level. Participitants with homocysteine levels between 5-13 µmol/L were identified as low-level group (I. group), homocysteine levels between 13-30 µmol/ L as middle-level group (II. group), female) and homocysteine level above 30 µmol/L as high-level group (III. group). After seperating sera homocysteine, methionine, cysteine, SAM and SAH were analyzed on HPLC system, folat and vitamin B12 were analyzed on hormon analyzer by electrochemiluminescence method. Results: The differences in methionine, cysteine, SAM, SAH, folate were statistically significant in three groups. Strong positive correlation was found between homocysteine and methionine. Conclusion: It was shown that methionine is syntesized in the case hyperhomocysteinemia and it was concluded that methionine might be non-essential in the case hyperhomocysteinemia. This result should be supported by studies with different protein contaning diets including more participants.

Full Text: PDF     DOI: 10.15640/ijhs.v4n1a9