Isoniazid Preventive Therapy Adherence among HIV Positive Patients in Selected Public Hospitals in Eastlands, Nairobi County, Kenya
Gladys Muthoni Kahianyu, Dr. Jackline Mosinya Nyaberi, Dr. Jane Rahedi Ong’ang’o, Dr. Francis Masiye

Aim: Globally, tuberculosis is the most common infection that contributes to the high rates of mortality and morbidity among people living with HIV/AIDS (PLHIV). Tuberculosis remains one of the top ten causes of death globally. The study specifically focused on patient-provider interaction, patient-related factors, and socio-environmental factors associated with the level of IPT adherence. Methods: The study used a descriptive cross-sectional study design. The study employed a mixed-methods approach, utilizing both quantitative and qualitative research methods. The study respondents were sampled using systematic sampling with a predetermined interval of 2 for the quantitative component of the study and purposive sampling for the qualitative part of the study. Results: The level of treatment adherence among PLHIV was 72.2% in Nairobi City County. The main reason for non-adherence was suspected active tuberculosis by healthcare providers. The majority of socio-patient-provider interaction factors were associated with IPT adherence, including provider attitude (p = 0.033), information (p = 0.008), and understanding of IPT (p = 0.049).Most patient-related factors, such as being persuaded to complete IPT (p = 0.028), fearing INH safety (p = 0.018), having cultural beliefs (p = 0.016), and believing in IPT treatment (p = 0.001), were significantly associated with IPT adherence. Conclusion: The study concludes that the rate of IPT adherence was below the acceptable standard of 90% in Nairobi City County.

Full Text: PDF     DOI: 10.15640/ijhs.v10n2a1